New Optical Imaging System Could Be Deployed to Find Tiny Tumors
March 8, 2019 | MITEstimated reading time: 4 minutes
Many types of cancer could be more easily treated if they were detected at an earlier stage. MIT researchers have now developed an imaging system, named “DOLPHIN,” which could enable them to find tiny tumors, as small as a couple of hundred cells, deep within the body.
In a new study, the researchers used their imaging system, which relies on near-infrared light, to track a 0.1-millimeter fluorescent probe through the digestive tract of a living mouse. They also showed that they can detect a signal to a tissue depth of 8 centimeters, far deeper than any existing biomedical optical imaging technique.
The researchers hope to adapt their imaging technology for early diagnosis of ovarian and other cancers that are currently difficult to detect until late stages.
“We want to be able to find cancer much earlier,” says Angela Belcher, the James Mason Crafts Professor of Biological Engineering and Materials Science at MIT and a member of the Koch Institute for Integrative Cancer Research, and the newly-appointed head of MIT’s Department of Biological Engineering. “Our goal is to find tiny tumors, and do so in a noninvasive way.”
Belcher is the senior author of the study, which appears in the March 7 issue of Scientific Reports. Xiangnan Dang, a former MIT postdoc, and Neelkanth Bardhan, a Mazumdar-Shaw International Oncology Fellow, are the lead authors of the study. Other authors include research scientists Jifa Qi and Ngozi Eze, former postdoc Li Gu, postdoc Ching-Wei Lin, graduate student Swati Kataria, and Paula Hammond, the David H. Koch Professor of Engineering, head of MIT’s Department of Chemical Engineering, and a member of the Koch Institute.
Deeper Imaging
Existing methods for imaging tumors all have limitations that prevent them from being useful for early cancer diagnosis. Most have a tradeoff between resolution and depth of imaging, and none of the optical imaging techniques can image deeper than about 3 centimeters into tissue. Commonly used scans such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) can image through the whole body; however, they can’t reliably identify tumors until they reach about 1 centimeter in size.
Belcher’s lab set out to develop new optical methods for cancer imaging several years ago, when they joined the Koch Institute. They wanted to develop technology that could image very small groups of cells deep within tissue and do so without any kind of radioactive labeling.
Near-infrared light, which has wavelengths from 900 to 1700 nanometers, is well-suited to tissue imaging because light with longer wavelengths doesn’t scatter as much as when it strikes objects, which allows the light to penetrate deeper into the tissue. To take advantage of this, the researchers used an approach known as hyperspectral imaging, which enables simultaneous imaging in multiple wavelengths of light.
The researchers tested their system with a variety of near-infrared fluorescent light-emitting probes, mainly sodium yttrium fluoride nanoparticles that have rare earth elements such as erbium, holmium, or praseodymium added through a process called doping. Depending on the choice of the doping element, each of these particles emits near-infrared fluorescent light of different wavelengths.
Page 1 of 2
Suggested Items
PCB Market Size to Grow by $29.06B from 2024-2028
05/17/2024 | PRNewswireThe global printed circuit board (PCB) market size is estimated to grow by USD 29.06 bn from 2024-2028, according to Technavio. The market is estimated to grow at a CAGR of over 6.6% during the forecast period.
Terran Orbital Joins the Mobile Satellite Services Association (MSSA)
05/16/2024 | BUSINESS WIRETerran Orbital Corporation, a global leader in satellite-based solutions primarily serving the aerospace and defense industries, announced its membership in the Mobile Satellite Services Association (MSSA).
Raytheon-Kongsberg System is Proving Itself – In Demos and In Combat
05/16/2024 | Raytheon TechnologiesOn a rocky island off the coast of Norway, Michael Sadlowski watched as a surface-to-air missile launcher pointed up into a dark nighttime sky.
Un-Jammable Quantum Tech Takes Flight to Boost UK’s Resilience Against Hostile Actors
05/13/2024 | BUSINESS WIREOSI Systems Receives Order for $9 Million to Provide Cargo and Vehicle Inspection Systems
05/13/2024 | BUSINESS WIREOSI Systems, Inc. announced that its Security division received an order from an international customer for approximately $9 million to provide the Company’s Eagle® M60 high energy mobile cargo and vehicle inspection systems including related service and support.